A lethal virus spreads throughout the British isles,infecting millions and killing hundreds of thousands. To contain the threat, acting authorities brutally quarantine the country as it succumbs to fear and chaos. The quarantine is successful. Three decades later, the Reaper virus violently resurfaces in a major city. An elite group of specialists, including Eden Sinclair, is urgently dispatched into the still-quarantined country to retrieve a cure by any means necessary. Shut off from the rest of the world, the unit must battle through a landscape that has become a waking nightmare.

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Amy Adams was born in Vicenza, Italy, the daughter of American parents Kathryn and Richard Adams, who was a U.S. serviceman stationed in Italy. She grew up as one of seven children in Castle Rock, Colorado and was raised in the Mormon religion, although her family left the church after Adams' parents divorced when she was 11 years old. Throughout her years at Douglas County High School, she sang in the school choir and trained as an apprentice at a local dance company with ambitions of becoming a ballerina. However, after graduating from high school, she decided that she was "never going to be that good [at ballet], no matter how hard she worked" and entered musical theater, which she found was "much better suited to her personality".