'Shoot 'Em Up' is about the near homeless Mr. Smith (Clive Owen), who during a gun battle with unknown men, saves a baby mid-delivery. The mother is shot in the head, leaving the infant all alone in the hands of Smith. Thinking the assassins were after the mother, he soon discovers that the baby is the actual target. As a result, Smith takes the newborn to a prostitute (Monica Bellucci) forming a makeshift family while on the constant run and under fire. Unless Smith uncovers the reason why the baby is being chased; his, the prostitute's and the child's lives are in grave danger.

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